Chiral Resolution Screening and Purification Kits 2017 by Acros

More catalogs by Acros | Chiral Resolution Screening and Purification Kits 2017 | 4 pages | 2017-07-18

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Catalog Chiral Resolution Screening and Purification Kits 2017

96 well plates glass vials glass vial nh3 isomer glass funnel filtration bath salts organic glass plate

Chiral Resolution Screening and Purification Kits 2017 is listed under these categories

Industrial Supply > Laboratory Equipment

Featured catalog pages of Chiral Resolution Screening and Purification Kits 2017

maybridge chiral resolution screening and purification kits offering rapid access to optically pure chiral

maybridge chiral resolution screening and purification kits introduction diastereomeric crystallization is a commonly used effective process to obtain optically pure chiral compounds from their racemic mixtures however choosing the optimal conditions for the process e.g combination of resolving agents and solvents is time-consuming tedious and labor-intensive maybridge chiral resolution screening and purification kits provide scientists with a quick and systematic approach to find the best separation conditions under which the target compound can be isolated with the highest yield and optical purity key features and benefits • rapid screening – the kits include 384 different combinations of resolving agents and solvents increasing the chances of finding the optimal separation conditions • high performance – development time reduced to one day • efficient – as little as 0.4mmol of racemate required • ready to use – resolving

how the kits work resolution of racemic chiral acids and amines can be achieved via the crystallization of their corresponding diastereomeric salt the racemic compound in this example a primary amine is treated with an enantiomerically pure organic acid in this case a carboxylic acid but sulfonic acids can be used as well diastereomeric salt formation nh3 nh3 co2h nh2 r r nh2 r1 r r2 r r1 r1 r3 r3 r3 r1 o2c o2 c r2 r2 under the right conditions one of the diastereomeric formed salts will precipitate as crystals whereas the other remains in solution it is then possible to separate the salts by filtering the precipitate and recrystallizing from a suitable solvent further recrystallizations are often required to achieve the desired purity of the product separation via crystallization nh3 nh3 r r r1 r3 o2 c r1 r crystallize r1 r3 r3 o2c r2 nh3 o2 c r2 r2 the amine can then be isolated using an alkaline aqueous work-up to give the free base regeneration of the single enantiomer nh3 r

transfer racemate to 96-well plate heat to ˜80°c until homogenous solutions are achieved remove transfer solvent cool until crystals form room temp or ice/water bath add recrystallization solvents analyze the vials with crystals recover racemate select best conditions and purify target isomers to desired purity yes conditions showing enantiomeric excess to purify the target isomer use the maybridge chiral purification and recovery kit thermo fisher scientific ena 23 zone 1 nr 1350 janssen pharmaceuticalaan 3a 2440 geel – belgium tel +32 14 57 52 11 fax +32 14 59 26 10 www.acros.com ©2012 thermo fisher scientific inc all rights reserved these brands and trademarks are part of thermo fisher scientific inc and its subsidiaries dissolve racemate in transfer solvent gc_mb_eem_1211_159 illustrated